My DNA results are in!

Most of my DNA results from 23andMe are in!

I’m looking over all the health information.  Some of the ancestry information is still being processed and will be a day or two away.

There are pages and pages and pages of interesting information here!  I’ll share the most fascinating.

According to my DNA:

Eye Colour: Likely Blue
Hair Curl: Straighter Hair on Average
Earwax Type: Wet

The average European shares 2.7% of their DNA with Neanderthals.  I share 2.8%.  Jeff said that explains a lot.

I have an 80% chance of being unable to taste bitter flavours. I have no idea if this is true because I have never tasted bitter food with anyone else’s tongue.

I am not resistant to HIV/AIDS or malaria. I have slightly higher odds of severe malarial anemia if infected with malaria.

I have an increased sensitivity to the drug Warfarin (Coumadin®) and may require a lower dose.

I have a greater tendency than the average woman to overeat.  I also am likely to consume more sugar daily than the average person.

My DNA will vary from my siblings, but Brian and Julie, if you don’t want to know about possible health risks that appeared in my results, stop reading NOW.

Decreased Risks:
Coronary Heart Disease: 0.59x average risk
Venous Thromboembolism: 0.72x
Age-related Macular Degeneration: 0.68x
Restless Legs Syndrome: 0.44x
Rheumatoid Arthritis: 0.40x
Melanoma: 0.75x
Parkinson’s Disease: 0.73x
Exfoliation Glaucoma: 0.80x
Multiple Sclerosis: 0.69x
Ulcerative Colitis: 0.78x
Crohn’s Disease: 0.79x

Elevated Risks:
Alzheimer’s Disease: 1.98x than average chance
Type 1 Diabetes: 2.10x average risk
Celiac Disease: 3.34x average risk
Esophageal Squamous Cell Carcinoma (ESCC): 1.21x average risk
Stomach Cancer (Gastric Cardia Adenocarcinoma): 1.22x

One of my Tuberculosis Susceptibility genetic markers shows a slightly higher odds of developing tuberculosis if exposed.

The interesting one to me is the increased risk of Alzheimer’s, which is known in my family tree. I apparently have “has one copy of the APOE ε4 variant. APOE ε4 is not the only factor contributing to Alzheimer’s disease. Although it is associated with increased risk of Alzheimer’s, many people with the APOE ε4 variant never develop it. ”  The report says, on average, 7.1 women with European ancestry out of 100 will develop Alzheimer’s between the ages of 50 and 79.  14.1 women of European ancestry who share my genotype out of 100 will develop Alzheimer’s between 50 and 79.  This is only looking at the genetic aspect of Alzheimer’s.  Environment and lifestyle may also play a role.

I also looked at the information for asthma. 2 of 3 reported markers in my DNA for asthma show that I have moderately higher odds of asthma, and slightly higher odds of having childhood asthma.  I’ve never had bad asthma, but it does cause a bit of trouble from time to time.

Inherited Conditions:

There are many inherited conditions listed, but I only have a variant for one of them.

I have one mutation in the HFE gene linked to hemochromatosis. A person with one of these mutations is not typically prone to higher levels of iron in the body, but can pass the mutation to offspring.

Ancestry:

This is just a very small sampling of the information.  I’m really excited for the ancestral results to be added, but I am unable to get anything from my father’s side because I am a female so I don’t have a Y chromosome.  Now I’m very keen on convincing more of my relatives to sign up to be tested, especially my father or brother, so I can learn more about my paternal side’s origins.

Haplogroup:

So far, I do know the Haplogroup of my maternal line.  It is “H1e2”.  I can’t find much specific information on it yet, but countries of origin will fill in when the rest of the results appear. It appears to be not so common.

What I can tell so far, is that  my mother’s people came from Europe, Near East, Central Asia, or Northwestern Africa.  H1e2 is a subgroup of H1.  25% of the Spanish population includes the H1 haplogroup.

H1 appears to have been common in Doggerland, an ancient land now flooded by the North Sea.

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